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DTSTART;TZID=America/Los_Angeles:20240528T110000
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SUMMARY:Cure GABA-A | What do we need to know about Gain of Function GABAAR
DESCRIPTION:What do we need to know about Gain of Function GABAA receptor variants?\n\n\nUnderstanding Gain of Function GABAA Receptor Variants\nGABAA Receptor Variants | Research Insights Session | Dr. Lidong Liu \nJoin us for an enlightening session with Dr. Lidong Liu\, Senior Research Scientist at the University of British Columbia’s Department of Neurology and the DM Centre for Brain Health. \nDr. Liu\, in collaboration with Dr. Yu Tian Wang\, focuses on the molecular mechanisms of synaptic function and plasticity\, particularly under conditions of health and disease. This session will describe GABAA receptor variants and their implications for epilepsy. \nThese groundbreaking insights are crucial for developing better treatments for conditions like epilepsy. Dr. Liu’s work highlights the dynamic interplay between neurotransmitter systems and offers new avenues for therapeutic intervention. \nEvent Details: \n\nDate: 5/28/2024\nTime: 11am PDT\n\nIf you cannot attend in person\, don’t worry—the session will be recorded and available on our YouTube channel. \nJoin us to learn from Dr. Liu’s expertise and contribute to our shared mission of improving the lives of patients with GABAA receptor variants. \nProject Overview: \n\nGABAA Receptor Study: This project focuses on understanding GABAA receptors.\nInitial Discovery: The first GABRA1 variant (A322D) was identified in epilepsy patients about 20 years ago.\nRecent Work: Recently\, more variants have been characterized\, and some repurposed drugs have been tested on these variants based on requests from doctors and patients’ families.\n\nKey Discoveries: \n\nGlutamate and GABAA Receptor Crosstalk:\nSignificance: There is an important interaction between glutamate and GABAA receptors.\nMechanism: Glutamate can bind to and enhance GABAA receptors to balance out the overexcitation caused by glutamate receptors.\nResearch Model: Mice with mutations in the glutamate binding site of GABAA receptors showed increased neuronal excitability\, seizure susceptibility\, and autism-like behaviors.\nNetrin-1’s Role:\nFunction: Netrin-1\, a molecule that guides axons\, is secreted during high neuronal activity.\nEffect: It binds to GABAA receptors and increases their function\, helping to balance synaptic activity by enhancing the conductance of these channels.
URL:https://curegabaa.org/event/cure-gaba-a-what-do-we-need-to-know-about-gain-of-function-gabaar/
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ORGANIZER;CN="CURE GABA-A":MAILTO:info@curegabaa.org
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