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DTSTART;TZID=America/Los_Angeles:20240208T110000
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DTSTAMP:20260419T221947
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SUMMARY:Cure GABA-A | Dr. Henry Lee |  Understanding of GABAergic Signaling
DESCRIPTION:Dr. Lee made a significant discovery highlighting the role of phosphorylation-dependent turnover of the potassium chloride co-transporter\n\n\nCure GABA-A | Webinar | Understanding of GABAergic Signaling \nJoin us for an educational session with Dr. Henry Lee. \nDr. Henry Lee is a molecular neurobiologist with a specialized interest in comprehending the molecular processes governing neuronal inhibition\, brain plasticity\, and functional recovery within the context of brain development and trauma. Through the integration of molecular biology and electrophysiology techniques\, Dr. Lee made a significant discovery highlighting the role of phosphorylation-dependent turnover of the potassium chloride co-transporter KCC2 in controlling Cl- mediated GABAergic inhibition (Lee et al.\, Nat Neurosci\, 2011). Employing innovative genetic mouse models\, he further investigated a paracrine signaling mechanism crucial for critical period (CP) plasticity control (Spatazza\, Lee et al.\, Cell Rep\, 2013; Lee et al.\, Mol Psychiatry\, 2017). \nDr. Lee’s translational research extends to the realm of functional recovery post-nerve damage (Bei\, Lee et al.\, Cell\, 2016) and traumatic brain injury (Hsieh\, Lee et al.\, Cerebral Cortex\, 2016). His recent focus centers on SSADH deficiency\, a rare inborn GABA metabolic disorder. Dr. Lee is actively engaged in the development of a specialized mouse tool for SSADH\, allowing ‘on-demand’ SSADH restoration. This endeavor is directed towards contributing to the preclinical advancement of innovative therapies for SSADH deficiency. \nJoin Cure GABA-A and Dr. Henry Lee on February 8th\, 2024\, at 11:00 PM PST for an educational session. For more details\, contact us on our socials or email: monica@cureGABAa.com. \nCan’t make it in person? Don’t worry – This session will be recorded and uploaded to the Cure GABA-A YouTube channel for your convenience. \n \nJoin us in our collective mission to improve the lives of patients with GABA-A Variants and work toward a brighter future.
URL:https://curegabaa.org/event/cure-gaba-a-dr-henry-lee-understanding-of-gabaergic-signaling/
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ORGANIZER;CN="CURE GABA-A":MAILTO:info@curegabaa.org
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DTSTART;TZID=America/Los_Angeles:20240205T110000
DTEND;TZID=America/Los_Angeles:20240205T120000
DTSTAMP:20260419T221947
CREATED:20240127T054422Z
LAST-MODIFIED:20240205T051057Z
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SUMMARY:Cure GABA-A | Educational Session | Importance of overnight EEG monitoring
DESCRIPTION:The Importance of overnight EEG monitoring when tracking genetic epilepsy and assessing the efficacy of treatment\n\n\nJoin us as Brad Levy from EEG2GO\, will share his incredible journey into the world of epilepsy and discuss “The Importance of overnight EEG monitoring when tracking genetic epilepsy and assessing the efficacy of treatment.” \nIn 2005\, Brad had no prior medical experience until his daughter’s sudden onset seizures and epilepsy diagnosis. He founded the Epilepsy Awareness Day at Disneyland\, which has grown into a significant annual event. This year’s event expected participation from around 100 epilepsy support groups and 2\,000 individuals. \nDriven by his passion for the Autism community\, Brad took on the challenge of creating an ideal EEG equipment and protocol in collaboration with Lifelines Neurodiagnostics and Dr. David Millett in 2015. He actively seeks out well-trained epilepsy specialists to enhance their referral network and speaking roster at the EAD Expo. \nToday\, Brad’s service offers patients an alternative to hospitals and inpatient EEG services\, focusing on comfort and data collection efficiency. \nJoin us as Brad highlights the importance of overnight EEG monitoring when tracking genetic epilepsy and assessing the efficacy of treatment. \nCan’t attend in person? No problem! This session will be recorded and available on our Cure GABA-A YouTube channel for your convenience. \nJoin us in our collective mission to improve the lives of patients with GABA-A Variants and work towards a brighter future.
URL:https://curegabaa.org/event/cure-gaba-a-educational-session-importance-of-overnight-eeg-monitoring/
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ORGANIZER;CN="CURE GABA-A":MAILTO:info@curegabaa.org
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DTSTART;TZID=America/Los_Angeles:20240129T100000
DTEND;TZID=America/Los_Angeles:20240129T110000
DTSTAMP:20260419T221947
CREATED:20240127T054416Z
LAST-MODIFIED:20240129T171220Z
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SUMMARY:Cure GABA-A | Family Presentation with Dr. Nazanin Azarinejad Mohammadi
DESCRIPTION:Unraveling GOF vs LOF GABRB2 Disease: Insights from Dr. Mohammadi’s Research\n\n\nJoin us for an educational session with Dr. Nazanin Azarinejad Mohammadi\, who recently defended her PhD thesis entitled “Clinical and functional characterization of GABAA-receptor related disorders: translating genetic diagnostics into personalized treatment” on 18.01.2024. \nUnder the guidance of Prof. Rikke S. Møller and Assoc. Prof. Philip K. Ahring\, Dr. Mohammadi’s groundbreaking research has unraveled the complexities of GOF (gain-of-function) vs LOF (loss-of-function) GABRB2 disease. \nIn her studies\, Dr. Mohammadi demonstrated\, for the first time\, that GABRB2 variants can lead to both GOF and LOF GABAA receptors\, with the associated phenotypes strongly linked to the functional outcome. Notably\, patients in the GOF group exhibited more severe phenotypes than those in the LOF group. \nAdditionally\, the research revealed that M1 proline substitutions in GABRA1\, GABRB2\, GABRB3\, or GABRG2 all result in GOF receptors\, indicating a subunit-independent functional effect. Patients with these variants displayed similar severe phenotypes\, aligning with their receptor function. \nDr. Mohammadi’s groundbreaking findings shed light on the intricate nature of genetic variants in the GABAA receptor\, showing their association with severe epilepsy and their ability to either decrease or increase the GABA sensitivity of the receptor. This discovery not only enhances genetic counseling for patients but also lays the foundation for the development of personalized treatment strategies. \nJoin Cure GABA-A and Dr. Nazanin Azarinejad Mohammadi on 1/29/2024 at 10:00am PST for an insightful exploration of GOF vs LOF GABRB2 disease. For more details\, contact us on our socials or email: . \nIf you are unable to attend in person\, rest assured – the session will be recorded and made available on the Cure GABA-A YouTube channel for your convenience. \n \nJoin us in our shared mission to enhance the lives of patients with GABA-A Variants and contribute to a brighter future.
URL:https://curegabaa.org/event/cure-gaba-a-family-presentation-with-dr-nazanin-azarinejad-mohammadi/
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ORGANIZER;CN="CURE GABA-A":MAILTO:info@curegabaa.org
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