GABRA2

What Is GABRA2

GABRA2 (Gamma-Aminobutyric Acid Receptor Alpha-2)

The GABRA2 gene is responsible for producing a protein called the alpha-2 subunit of the GABA-A receptor. This receptor is present in the brain and helps regulate the activity of the nervous system.

Think of the GABA-A receptor as a lock on the surface of brain cells, and GABA (gamma-aminobutyric acid) as the key that fits into this lock. When GABA binds to the GABA-A receptor, it causes a calming or inhibitory effect on the brain, helping to reduce anxiety and promote relaxation. Read More

Symptoms of GABRA2

Variations in the GABRA2 gene have been studied in relation to alcohol dependence and related behaviors. However, it’s important to note that the relationship between GABRA2 variations and symptoms is complex, and further research is needed to fully understand the implications.

Here are some findings that have been reported in studies investigating GABRA2:

  1. Alcohol dependence: Certain variations in the GABRA2 gene have been associated with an increased risk of alcohol dependence. Individuals with specific GABRA2 genotypes may have a higher susceptibility to developing alcohol use disorder.
  2. Alcohol-related behaviors: Variations in GABRA2 have also been linked to specific alcohol-related behaviors, such as increased subjective response to alcohol, heightened sensitivity to the effects of alcohol, and higher levels of alcohol consumption.
  3. Anxiety and stress-related symptoms: Some studies have suggested an association between GABRA2 variations and increased vulnerability to anxiety disorders and stress-related symptoms, although the evidence is not conclusive.
  4. There is limited evidence or association reported between GABRA2 (Gamma-Aminobutyric Acid Receptor Alpha-2) and developmental and epileptic encephalopathy (DEE)
  5. Modifier Gene: Variations in the GABRA2 gene can influence other epilepsy-associated genes, like SCN1A and SCN8A.

It’s important to note that the symptoms and severity of these conditions can vary widely among individuals, even among those with the same genetic variation. Additionally, further research is needed to fully understand the relationship between GABRA2 gene variations and the associated symptoms and conditions.

If you have specific concerns about GABRA2 gene variations or related conditions, it is recommended to consult with a healthcare professional or a geneticist who can provide you with the most up-to-date and accurate information based on your specific situation. They can conduct a thorough evaluation and provide appropriate guidance and support.

Disclaimer: It is important to note that our understanding of GABA A Variants and their associated symptoms is an ongoing area of research. As of now, there may still be limited information available regarding the specific symptoms and implications of these genetic variations. It is recommended to consult with healthcare professionals or genetic specialists, and stay updated with the latest scientific research, as ongoing studies and advancements may provide further insights into GABA A Variants and their related symptoms.

Cure GABA A Variants non-profit and cureGABAa.org does not provide medical advice. It is intended for informational purposes only. It is not a substitute for professional medical advice, diagnosis or treatment. It does not diagnose, it produces a ranked list of suspected genes which provide assistance for rare hereditary disease cases. Patients should discuss their findings with their healthcare provider. Cure GABA A Variants does not intend to diagnose patients. It is providing information in order for patients to find and get better management of expert certified clinical assistance.